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So just to mention, maybe one of the most, well-known is a POMC/CART neuron in the hypothalamus

Conclusion GLP-1 medications have proven to be effective for management of diabetes as well as for weight loss in those without diabetes, especially when combined with a healthy diet and adequate exercise

Helmstdter J, Keppeler K, Kster L, Mnzel T, Daiber A, Steven S (2022) Glucagon- like peptide-1 (GLP-1) receptor agonists and their cardiovascular benefits-The role of the GLP-1 receptor

In addition, the insulinotropic effect of the dual GIP/GLP-1 receptor agonist was abrogated by GIP receptor antagonist (GIPRA) in GLP-1R null mice (63)

The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice

One unanswered question is whether long-term use could lead to reduced responsiveness over time